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. Author manuscript; available in PMC: 2015 Sep 17.
Published in final edited form as: FEBS Lett. 2014 Aug 14;588(18):3501–3510. doi: 10.1016/j.febslet.2014.08.009

Fig. 4.

Fig. 4

TNF-α and IL-6 cytokine induction mediated by HCV core is dependent on MAP kinases. THP-1 macrophages (A and B) and MDMs (C and D) were stimulated with HCV core or β-galactosidase protein control in the presence or absence of 50 μM SP600125 (JNK inhibitor), 20 μM SB203580 (p38 inhibitor), 50 μM PD98059 (MEK1/2 inhibitor), and 10 μM U0126 (MEK1/2 inhibitor). TNF-α (A and C) and IL-6 (B and D) induction was determined by ELISA (R&D Systems, Minneapolis, MN) 14 hours after stimulation. Results from 3 independent experiments (THP-1) and 2 independent MDM donors are shown. Data are means ± SD. *Significantly different (P < 0.05) from HCV core–stimulated group.