Skip to main content
. Author manuscript; available in PMC: 2014 Sep 18.
Published in final edited form as: Comb Chem High Throughput Screen. 2014 Mar;17(3):210–230. doi: 10.2174/1386207317666140109121546

Figure 8.

Figure 8

A) Chemical structure of the UMI-77; B) Dose-response competitive binding curves of UMI-77 against five members of Bcl-2 family obtained by FP based binding assay; C) The docked structure of UMI-77 at the canonical BH3 binding pocket of Mcl-1. The hydrophobic interactions of para-bromophenyl group and naphthalenering are labeled with green dots, while the hydrogen bonds with yellow dots. D) The in vivo efficacy of UMI-77 in BxPC-3 xenograft animal model. BxPC-3 xenografts were inoculated subcutaneously in SCID mice. Mice were administered UMI-77 i.v 60 mg/kg for 5 consecutive days a week for two weeks.