Table 2.
Colorectal adenoma risk associated with dietary HAA intake and exposure to meat mutagenicity in the total study population and separately among females and males
| Categoriesa | N b | Total adjusted ORc (95 % CI) | N b | Females adjusted ORc (95 % CI) | N b | Males adjusted ORc (95 % CI) | |
|---|---|---|---|---|---|---|---|
| PhIP | ≤116.30 | 55/36 | Referent | 37/19 | Referent | 18/17 | Referent |
| 116.31–232.61 | 66/32 | 0.73 (0.37, 1.44) | 43/8 | 0.44 (0.16, 1.20) | 23/24 | 1.34 (0.52, 3.50) | |
| 232.62–348.91 | 39/18 | 0.60 (0.26, 1.35) | 27/5 | 0.32 (0.10, 1.04) | 12/13 | 1.27 (0.39, 4.10) | |
| >348.92 | 53/37 | 0.99 (0.49, 1.97) | 41/13 | 0.56 (0.23, 1.38) | 12/24 | 2.14 (0.74, 6.51) | |
| MeIQx | ≤18.54 | 75/32 | Referent | 54/12 | Referent | 21/20 | Referent |
| 18.55–37.09 | 56/32 | 1.38 (0.68, 2.78) | 38/13 | 1.94 (0.74, 5.07) | 18/19 | 0.97 (0.36, 2.61) | |
| 37.10–55.63 | 29/26 | 2.18 (1.02, 4.68) | 19/10 | 2.39 (0.81, 7.08) | 10/16 | 2.02 (0.68, 5.94) | |
| >55.64 | 53/33 | 1.25 (0.62, 2.50) | 37/10 | 0.94 (0.34, 2.55) | 16/23 | 1.67 (0.63, 4.51) | |
| DiMeIQx | ≤2.06 | 73/37 | Referent | 54/16 | Referent | 19/21 | Referent |
| 2.07–4.12 | 58/29 | 0.78 (0.39, 1.58) | 38/10 | 0.79 (0.30, 2.08) | 20/19 | 0.79 (0.30, 2.13) | |
| 4.13–6.18 | 29/22 | 1.24 (0.57, 2.71) | 18/10 | 1.58 (0.56, 4.46) | 11/12 | 0.97 (0.32, 2.98) | |
| >6.19 | 53/35 | 1.17 (0.59, 2.30) | 38/9 | 0.68 (0.26, 1.79) | 15/26 | 1.98 (0.73, 5.37) | |
| Meat mutagenicity | ≤3,589.83 | 54/29 | Referent | 40/13 | Referent | 14/16 | Referent |
| 3,589.84–7,179.67 | 71/33 | 0.88 (0.44, 1.78) | 47/14 | 0.96 (0.38, 2.44) | 24/19 | 0.75 (0.31, 2.39) | |
| 7,179.68–10,769.50 | 35/26 | 0.98 (0.44, 2.15) | 19/8 | 1.09 (0.36, 3.33) | 16/18 | 1.01 (0.34, 2.98) | |
| >10,769.51 | 53/35 | 1.17 (0.57, 2.42) | 42/10 | 0.63 (0.23, 1.71) | 11/25 | 2.58 (0.84, 7.94) |
Bolded text indicate statistically significant relationships
aUnits: ng/day for HAAs and number of revertant colonies/day for meat mutagenicity
b N for non-events/N for events; total of 336 participants with complete data
cAdjusted for sex, smoking status, fruit and vegetable intake, dietary fiber intake and biomarker levels of albumin and folate