Skip to main content
. Author manuscript; available in PMC: 2014 Sep 18.
Published in final edited form as: Mol Carcinog. 2005 Nov;44(3):174–182. doi: 10.1002/mc.20122

Figure 1.

Figure 1

(A) UV and BPDE treatment but not IR downregulate expression of fragile site genes, WWOX and FHIT. MCF-7 cells were exposed to UV, BPDE, and IR, as described in Materials and Methods. Northern blots of total RNA (20 µg per lane) were hybridized with probes for WWOX, FHIT, p21, and GAPDH genes, as indicated. (B) Cell viability of treated cells. Cell viability was determined by trypan-blue exclusion and is expressed as a percentage of untreated controls. (C) UV, BPDE, and IR treatment resulted in cell growth arrest. Total viable cell number was determined by trypan-blue exclusion 24 h posttreatment. Each treatment was performed in triplicate and is represented as the average ±SD.