Table 3.

Association between daily intake of dietary variables and Boyd's % breast density classification, among 3,548 women from the DDM-Spain study

	All women1			Pre- and perimenopausal1			Postmenopausal1
Dietary variables	OR2	95% CI3	p	OR2	95% CI3	p	OR2	95% CI3	p	p heterogeneity4
Calories
<706 Kcals	1.00	–	–	1.00	–	–	1.00	–	–	0.299
1,706–2,018 Kcals	1.02	0.85–1.23	0.838	0.77	0.51–1.17	0.229	1.15	0.93–1.41	0.201
2,019–2,352 Kcals	1.08	0.89–1.32	0.418	0.92	0.59–1.42	0.703	1.22	0.97–1.52	0.085
>2,352 Kcals	1.34	1.03–1.74	0.027	1.16	0.68–2.00	0.584	1.50	1.11–2.03	0.008
per 500 Kcals5	1.23	1.10–1.38	<0.001	1.23	0.97–1–54	0.082	1.23	1.08–1.40	0.001
Proteins
85 g	1.00	–	–	1.00	–	–	1.00	–	–	0.122
85–99 g	0.94	0.78–1.13	0.512	0.85	0.57–1.28	0.445	0.96	0.78–1.18	0.717
100–116 g	0.80	0.66–0.99	0.039	0.71	0.46–1.12	0.140	0.81	0.64–1.03	0.080
>116 g	0.79	0.61–1.02	0.075	0.60	0.35–1.03	0.067	0.84	0.63–1.14	0.264
per 25 g5	0.89	0.80–1.00	0.042	0.93	0.74–1.17	0.534	0.87	0.76–0.98	0.023
Olive oil
<12 g	1.00	–	–	1.00	–	–	1.00	–	–	0.467
12–48 g	0.85	0.73–0.98	0.026	0.87	0.65–1.16	0.339	0.86	0.73–1.01	0.062
>48 g	0.72	0.56–0.93	0.010	0.63	0.40–0.99	0.045	0.76	0.57–1.02	0.069
per 22 g5	0.86	0.76–0.96	0.008	0.85	0.69–1.05	0.136	0.86	0.76–0.98	0.026
Whole milk
0 g	1.00	–	–	1.00	–	–	1.00	–	–	0.609
1–200 g	1.07	0.87–1.31	0.551	1.04	0.69–1.59	0.840	1.06	0.83–1.34	0.647
>200 g	1.30	1.01–1.68	0.044	1.36	0.85–2.19	0.203	1.21	0.89–1.64	0.217
per 100 g5	1.10	1.00–1.20	0.039	1.14	0.96–1.36	0.124	1.06	0.96–1.18	0.258
Cereals and pasta
<43.8g	1.00	–	–	1.00	–	–	1.00	–	–	0.272
43.8–48.9 g	0.95	0.74–1.22	0.694	1.00	0.60–1.68	0.990	0.93	0.70–1.24	0.623
49.0–87.0 g	1.00	0.86–1.17	0.951	1.12	0.81–1.56	0.479	0.97	0.82–1.16	0.769
>87.0 g	1.14	0.96–1.36	0.123	1.17	0.84–1.63	0.346	1.11	0.93–1.34	0.252
per 40 g5	1.08	0.99–1.18	0.074	1.12	0.95–1.31	0.182	1.05	0.97–1.17	0.195
White meat
<19g	1.00	–	–	1.00	–	–	1.00	–	–	0.278
19–40 g	1.04	0.88–1.21	0.668	1.03	0.74–1.44	0.860	1.06	0.89–1.27	0.491
40.1–51.4 g	0.89	0.73–1.10	0.293	1.04	0.67–1.61	0.852	0.89	0.70–1.12	0.326
>51.4 g	0.93	0.76–1.14	0.489	1.19	0.79–1.80	0.402	0.96	0.77–1.20	0.728
per 20 g5	0.89	0.80–1.00	0.041	1.05	0.85–1.33	0.593	0.90	0.80–1.02	0.108
Nuts
0 g	1.00	–	–	1.00	–	–	1.00	–	–	0.312
1–2 g	1.06	0.89–1.25	0.521	0.95	0.66–1.37	0.798	1.05	0.87–1.28	0.592
3–22g	1.03	0.88–1.21	0.718	1.00	0.71–1.41	0.989	1.05	0.88–1.26	0.601
>23 g	1.13	0.91–1.40	0.258	1.43	0.88–2.30	0.145	1.10	0.86–1.40	0.453
per 10 g5	1.06	1.00–1.13	0.060	1.14	1.00–1.30	0.046	1.05	0.97–1.17	0.195

¹All the multivariate models were adjusted for daily calorie intake, proteins, alcohol intake, body mass index, smoking habit (current/former/never), menopausal status, number of births, and for screening center as a random effects term.

²OR: Odds ratio.

³CI: Confidence Interval.

⁴Statistical significance of the interaction term between menopausal status and the corresponding dietary variable.

⁵Linear trend.