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. 2013 Sep 10;231(2):158–167. doi: 10.1002/path.4240

Figure 4.

Figure 4

Knock-down of UBR5–ZNF423 inhibits cell proliferation and colony formation of NPC cells. (a) Expression of UBR5–ZNF423 was knocked down by the fusion-specific siRNA. The suppression of UBR5–ZNF423 in C666-1 was confirmed by quantitative RT–PCR and western blotting. (b) WST-1 assay demonstrated that cell proliferation was significantly reduced in C666-1 treated with siRNAs (S1 and S2) targeting UBR5–ZNF423 fusion. (c) Knock-down of UBR5–ZNF423 by siRNA significantly inhibited the colony-forming ability of C666-1 cells.