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. 2013 Sep 10;231(2):158–167. doi: 10.1002/path.4240

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© 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Transforming activity of UBR5–ZNF423. (a) By western blotting, the expression of UBR5–ZNF423 fusion protein in the stable UBR5–ZNF423-transfected NIH3T3 cells and tumours dissected from the xenografts (T1–T4) was detected; ^*non-specific bands. (b) Stable expression of UBR5–ZNF423 induces the anchorage-independent growth of NIH3T3 cells. Significant increase in number and size of colonies in the stable UBR5–ZNF423-expressing cells was demonstrated by soft agar assay. (c) In vivo tumourgenic assay in nude mice showed that tumours formed in the sites implanted with NIH3T3 cells expressing UBR5–ZNF423 (T1–T4, red arrows) were consistently larger than those implanted with vector controls (N1–N4, green arrows).