Figure 1. Influence of FSHR -29G>A and FSHB -211G>T on age at pubertal onset in 964 healthy Danish girls.

Left panel: The number of girls and their mean age at pubertal onset according to FSHR -29G>A genotypes (A) and the combined genotypes of FSHR -29G>A and FSHB -211G>T (B). In the combined model, we tested if there was an additive effect of the minor alleles across the genotypes (FSHR -29A and FSHB -211T). The fading green/yellow/red bars indicate intermediate FSH production and FSH receptor expression, respectively, in the heterozygotes compared with the wild-types and the minor allele homozygotes. The colours correspond to the subgroups of combined genotypes: 0 minor alleles: dark green; 1 minor allele: light green; 2 minor alleles: orange; 3 minor alleles: red; No girls had 4 minor alleles (C). Right panel: Mean age at pubertal onset (95% CI) according to FSHR -29G>A genotypes (A) and the combined genotypes of FSHR -29G>A and FSHB -211G>T (B). The combined model revealed additive effect of the minor alleles across the genotypes (B). The outline of the figure is inspired by Tuttelmann et al.⁴⁸.