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Phenotype of MuRF1-null [knockout (KO)] mice. The major differences in the response of the MuRF1-KO mice relative to WT mice are highlighted for glucocorticoid treatment, denervation, and aging (18–24 mo old). A common phenotype of all of the models is muscle sparing. Nedd4, neural precursor cell expressed developmentally downregulated protein 4; HDAC4, histone deacetylase 4; ER, endoplasmic reticulum.
