Table 1.
Atrophy models that have shown MuRF1 and MAFbx to be upregulated
| Model | Gene | Species | Ref. Nos. |
|---|---|---|---|
| Fasting | MAFbx | Mouse | 36, 51, 66 |
| MuRF1 and MAFbx | Mouse | 3, 87, 111 | |
| Glucocorticoids | MuRF1 and MAFbx | Mouse | 7, 15, 176 |
| MuRF1 | Rat | 4, 187 | |
| MAFbx | Rat | 188, 196 | |
| MuRF1 and MAFbx | Rat | 191 | |
| Denervation | MuRF1 and MAFbx | Mouse | 15, 111, 146 |
| MuRF1 and MAFbx | Rat | 193 | |
| Spinal cord transection | MuRF1 and MAFbx | Mouse | 146 |
| MuRF1 and MAFbx | Rat | 193 | |
| MuRF1 and MAFbx | Human | 172 | |
| Hindlimb suspension | MuRF1 and MAFbx | Mouse | 15, 58 |
| MuRF1 and MAFbx | Rat | 100 | |
| Immobilization | MuRF1 and MAFbx | Mouse | 15, 22, 123 |
| MuRF1 | Rat | 73 | |
| MAFbx | Rat | 166 | |
| MuRF1 and MAFbx | Rat | 11, 78 | |
| MuRF1 | Human | 35 | |
| MAFbx | Human | 69 | |
| MuRF1 and MAFbx | Human | 25, 56 | |
| Bed rest | MAFbx | Human | 122 |
| ICU mimic | MuRF1 and MAFbx | Rat | 120 |
| Mechanical ventilation | MuRF1 and MAFbx | Mouse | 168 |
| MAFbx | Rabbit | 197 | |
| MuRF1 and MAFbx | Human | 93 | |
| Chronic kidney disease | MuRF1 and MAFbx | Mouse | 87 |
| Diabetes | MAFbx | Mouse | 26, 36, 61 |
| MuRF1 and MAFbx | Mouse | 87, 179 | |
| MAFbx | Rat | 89 | |
| Sepsis | MuRF1 and MAFbx | Rat | 45, 185 |
| LPS injection | MuRF1 and MAFbx | Mouse | 40 |
| MuRF1 and MAFbx | Rat | 37 | |
| Cachexia | MAFbx | Mouse | 130 |
| MuRF1 and MAFbx | Mouse | 6, 87, 98, 158 | |
| MuRF1 and MAFbx | Rat | 33 | |
| HIV | MAFbx | Rat | 124, 141 |
| COPD | MAFbx | Human | 92, 126, 136, 169 |
| MuRF1 and MAFbx | Human | 39 | |
| Aging | MuRF1 | Rat | 5 |
| MuRF1 and MAFbx | Rat | 30 | |
| MuRF1 | Human | 142 | |
| ALS | MAFbx | Human | 91 |
| Alcohol | MuRF1 and MAFbx | Rat | 125, 175 |
| Spinal muscular atrophy | MuRF1 and MAFbx | Mouse and Human | 19 |
| Heart failure | MuRF1 and MAFbx | Rat | 23 |
| Space flight | MAFbx | Mouse | 2 |
| MuRF1 | Rat | 119 | |
| Thermal injury | MuRF1 and MAFbx | Rat | 85, 156 |
| Inflammatory cytokines | MuRF1 | Mouse | 1 |
| MAFbx | Mouse | 96, 106 | |
| MuRF1 and MAFbx | Mouse | 15 | |
| Smoking | MAFbx | Human | 133 |
| Myositis | MAFbx | Human | 88 |
| Acute lung injury | MuRF1 and MAFbx | Mouse | 43 |
| Statins | MAFbx | Humans | 57 |
| Arthritis | MuRF1 and MAFbx | Rat | 55 |
| Pulmonary arterial hypertension | MuRF1 and MAFbx | Human | 14 |
| Hypoxia | MuRF1 and MAFbx | Mouse | 38a |
| Knee arthroplasty | MuRF1 and MAFbx | Human | 9 |
MuRF1, muscle RING finger 1; MAFbx, muscle atrophy F-box; COPD, chronic obstructive pulmonary disease. List of atrophy models in which MuRF1 and/or MAFbx have been shown to be upregulated.