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. 2014 Jul 17;307(6):G595–G601. doi: 10.1152/ajpgi.00159.2014

Fig. 3.

Fig. 3.

A: quantitative data show the time course of the IAS relaxation with electrical field stimulation (EFS, 5 Hz) in control that is significantly suppressed by hemin pretreatment (8; P < 0.05; n = 4). SnPPIX pretreatment in the hemin-pretreated IAS strips blocks the blunted EFS response so that the EFS responses in the presence of the combination are not significantly different from control (P > 0.05; n = 4). Data further show significant increase in the velocities of the relaxation and recovery of the IAS relaxation with EFS (*P < 0.05; n = 4) calculated by the extrapolated regression lines drawn (as broken lines) by the software. Note: for clarity, regression lines are drawn only for the relaxation phase and not for the recovery of relaxation phase. B: quantitative data show the frequency-dependent relaxation of the IAS that is significantly attenuated by hemin pretreatment (*P < 0.05; n = 4), reversible to the control levels by SnPPIX (P > 0.05).