Table 2.

[ureido-¹⁵N]citrulline and [¹⁵N₄]arginine kinetics in sham (SHAM) and kidney-ligated (LIG) mice

	SHAM	LIG	P
[ureido-15N]citrulline
AUC0-∞, μmol/min	1,012 ± 98	1,726 ± 155	<0.011
AUC0–70 min, μmol/min	998 ± 99	1,588 ± 77	<0.003
AUMC, μmol/min2	27,340 ± 5,076	86,845 ± 15,310	<0.021
λ, min	23.5 ± 3.0	38.7 ± 3.3	<0.014
MRT, min	26.7 ± 3.5	49.2 ± 4.3	<0.007
[15N]arginine
AUC0–70 min, μmol/min	351 ± 8.5	85 ± 3.6	<0.001
Recovered, μmol	0.74 ± 0.06	0.17 ± 0.01	<0.001
As % infused [15N]citrulline	61.7 ± 5.22	14.2 ± 0.48	<0.001
[15N4]arginine
AUC0–70 min, μmol/min	297 ± 18	315 ± 27.2	<0.597

Values are means ± SE; n = 5.

AUC, area under the curve; AUMC, area under the moment curve; λ, half-life; MRT, mean retention time.