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Effects of UCL 1684 on responses of PDGFRα+ cells to ADPR. A: effects of ADPR (10 μM) before and after pretreatment with UCL 1684 to block the small-amplitude Ca2+-activated K+ (SK) portion of the response. Addition of UCL 1684 (1 μM) blocked only part of the hyperpolarization response elicited by ADPR. B: summary of effects of UCL 1684 on ADPR responses. UCL 1684 significantly, but not quantitatively, reduced the hyperpolarization response to ADPR (n = 4). *P = 0.0214.
