Fig. 6.

Effects of cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine (CyPPA) on PDGFRα⁺ cells and SMCs. A: current-clamp recording from a PDGFRα⁺ cell using the dialyzed whole cell configuration (I = 0). CyPPA (30 μM) evoked repeatable hyperpolarization responses in the PDGFRα⁺ cell, with a peak at about −80 mV. B: current-clamp recording (I = 0) in a SMC with the perforated-patch whole cell configuration. CyPPA (30 μM) elicited repeatable small hyperpolarization responses in the SMC. C: summary graphs of CyPPA effects in PDGFRα⁺ cells (n = 6) and SMCs (n = 6). Responses in SMCs were smaller than responses in PDGFRα⁺ cells. *P = 0.0003 (by unpaired t-test).