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Effects of caveolin-3 (Cav-3) knockout (KO) on ischemia-reperfusion (I/R) tolerance and protection via SLP. Data are shown for postischemic EDP (in mmHg; A), LVDP (in %; B), and LDH release (C). Responses were assessed in wild-type (CTRL) and Cav-3 KO hearts from untreated or SLP-treated mice (5-day morphine pellet). Values are means ± SE; for all groups, n ≥ 7. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. CTRL mice; †P < 0.05 vs. Cav-3 KO mice.
