Table 2.
Log EC50 values for PE, UK 14304, and ACh for FA and arterioles in young and old mice
| PE |
UK 14304 |
ACh |
||||
|---|---|---|---|---|---|---|
| Vessel Branch | Young | Old | Young | Old | Young | Old |
| FA | −6.4 ± 0.1 | −6.4 ± 0.1 | −6.2 ± 0.2 | −6.4 ± 0.3 | −7.5 ± 0.1 | −7.4 ± 0.1 |
| 1A | −6.3 ± 0.1 | −6.3 ± 0.1 | −6.5 ± 0.2 | −6.3 ± 0.2 | −7.0 ± 0.1 | −6.9 ± 0.1 |
| 2A | −5.9 ± 0.1 | −6.4 ± 0.1 | −6.7 ± 0.1 | −6.5 ± 0.2 | −6.4 ± 0.1 | −6.9 ± 0.1 |
| 3A | −6.4 ± 0.1 | −6.5 ± 0.1 | −7.2 ± 0.2 | −6.5 ± 0.2 | −6.2 ± 0.1 | −6.7 ± 0.1 |
Values are means ± SE; n = 5 per group. One vessel from each branch order was studied in each GM preparation. With EC50 values as an index, vascular sensitivity to phenylephrine (PE), UK 14304, and ACh was not significantly different between age groups as determined by using 2-way ANOVA.