Table 2.

Measurements of serum osmolality and sodium, hematocrit, protein, and liver weight-to-body weight ratio in sham and bile duct ligated rats injected with a viral construct containing either a scrambled control shRNA or a shRNA targeted to AT1aR

	n	Osmolality, mOsm/kg	Serum Sodium, mEq/l	Hematocrit, %	Plasma Protein, g/dl	Liver Wt/Body Wt	Final Body Weight, g
Sham SCM	12	308 ± 1	166 ± 5	48 ± 1	7.6 ± 0.1	0.035 ± 0.002	484 ± 19
Sham sh-AT1a	18	304 ± 1	161 ± 4	48 ± 1	7.7 ± 0.1	0.031 ± 0.001	495 ± 9
BDL SCM	12	302 ± 1†	153 ± 4†	44 ± 1*	7.7 ± 0.1	0.070 ± 0.002*	470 ± 8
BDL sh-AT1a	16	300 ± 1*	146 ± 3*	44 ± 1*	7.7 ± 0.1	0.075 ± 0.004*	458 ± 13

Data are expressed as means ± SE.

BDL, bile duct ligated; SCM, scrambled control shRNA; sh-AT_1a, shRNA targeted to AT_1aR.

^*P < 0.01 compared to sham groups.

^†P < 0.05 compared to sham SCM group.