A: adhesion of leukocytes to endothelium. B: leukocyte emigration. C: wall shear rate. Mice were treated with saline (Saline group), with LPS and anti-KC:KC ICs (ALI group), with LPS and F(ab)2 fragments of anti-neutrophil antibodies and ICs [ALI/F(ab)2 group], with LPS and siRNA for MMP-9 conjugated with F(ab)2 fragments and ICs (ALI/siRNA MMP-9 group). D: number of cells: lymphocytes, neutrophils, total leukocytes in circulation of mice treated with saline (Saline group), with LPS and anti-KC:KC ICs (ALI group), with LPS and F(ab)2 fragments and ICs [ALI/F(ab)2 group], with LPS and siRNA for MMP-9 conjugated with F(ab)2 fragments and ICs (ALI/siRNA MMP-9 group). Four to 6 mice per group were analyzed and typical findings are presented. In A–D samples were collected at 14 h after anti-KC:KC IC administration.