Table 3.
Lung Injury Score |
|||
---|---|---|---|
Edema fluid | Thickening of alveolar septa | Inflammatory infiltration | |
Saline | 0.129 ± 0.177 | 0.055 ± 0.124 | 0.206 ± 0.034 |
ALI | 1.468 ± 0.245* | 1.718 ± 0.216* | 1.925 ± 0.083* |
ALI/siRNA Btk | 0.163 ± 0.090 | 0.055 ± 0.056 | 0.277 ± 0.109 |
ALI/Cont siRNA | 1.337 ± 0.170** | 1.607 ± 0.276** | 1.824 ± 0.141** |
ALI/F(ab)2 only | 1.640 ± 0.221§ | 1.742 ± 0.099§ | 1.728 ± 0.071§ |
ALI/siRNA MMP-9 | 0.069 ± 0.055 | 0.133 ± 0.194 | 0.230 ± 0.171 |
Values are means ± SD. Analysis was done for 4–5 animals per group.
P < 0.001 compared with Saline; ALI/siRNA Btk; ALI/siRNA MMP-9 groups of mice.
P < 0.001 compared with Saline; ALI/siRNA Btk; ALI/siRNA MMP-9 groups of mice.
P < 0.001 compared with Saline; ALI/siRNA Btk; ALI/siRNA MMP-9 groups of mice.