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. 2014 Sep 18;2:71. doi: 10.3389/fchem.2014.00071

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Copyright © 2014 Rodriguez, Papanastasiou, Juba and Bishop.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antibacterial effectiveness of P4LC, Pep-4, Pep-4/LVFX and LVFX against E. coli (A,C,E) and B. cereus (B,D,F). The top row (A,B) were generated for assays performed in low total ionic strength (26 mM), the middle row (C,D) for intermediate total ionic strength (111 mM), and the bottom row (E,F) for high total ionic strength (167 mM) conditions. Data were fit to equation 3, a standard variable slope dose-response equation, in order to obtain EC₅₀ values. Pep-4 failed to achieve sufficient killing (within the tested peptide concentration range) to define the lower survival boundary for fitting to Equation 3 under higher ionic strength conditions (D–F), and it was necessary to set the lower boundary to 0. Curves based on the data constraints are shown in red.