Table 4.

Laboratory and clinical characteristics

Characteristics (all parameters), mean ± SD	CSA group	TAC group	P-value
Creatinine (mg/dL)
Baseline	1.1±0.5	1.5±0.8	<0.0001
2 years after HTX	1.4±0.4a	1.7±1.3b	ns
MDRD (mL/min*1.73 m2)
Baseline	82.4±34.2	67.6±40.7	0.0030
2 years after HTX	61.3±25.0a	57.6±24.9a	ns
Sodium (mmol/L)
Baseline	136.5±3.8	137.5±3.4	0.0428
2 years after HTX	138.6±3.5a	139.2±2.8a	ns
Potassium (mmol/L)
Baseline	4.2±0.5	4.3±0.6	ns
2 years after HTX	4.3±0.4b	4.4±0.5b	ns
Serum urea (mg/dL)
Baseline	69.7±45.3	78.6±41.4	ns
2 years after HTX	56.8±20.1a	57.3±25.8b	ns
Uric acid (mg/dL)
Baseline	5.9±2.3	6.8±2.6	0.0075
2 years after HTX	6.6±1.9a	6.8±2.2b	ns
Blood glucose trough level (mg/dL)
Baseline	117.2±49.7	127.0±56.4	ns
2 years after HTX	109.2±30.2b	114.0±37.0b	ns
Creatine phosphokinase (U/L)
Baseline	23.3±23.3	35.9±21.8	<0.0001
2 years after HTX	141.0±157.3a	150.8±142.9a	ns
ASAT (U/L)
Baseline	17.3±10.7	24.2±16.7	0.0007
2 years after HTX	16.4±8.3b	29.8±32.8b	0.0014
ALAT (U/L)
Baseline	35.7±31.3	49.0±36.7	0.0048
2 years after HTX	17.6±13.6a	24.3±15.2a	0.0061
GGT (U/L)
Baseline	111.7±112.0	306.4±271.1	<0.0001
2 years after HTX	30.6±29.7a	83.3±99.4a	<0.0001
Total blood cholesterol level (mg/dL)
Baseline	220.5±56.6	198.0±50.1	0.0021
2 years after HTX	193.7±46.6a	178.1±35.5a	0.0252
HDL (mg/dL)
Baseline	60.3±22.5	61.4±20.6	ns
2 years after HTX	48.7±15.6a	50.1±16.3a	ns
LDL (mg/dL)
Baseline	128.9±48.1	104.2±32.4	0.0002
2 years after HTX	114.0±30.5a	95.8±31.4b	0.0006
Triglycerides (mg/dL)
Baseline	184.5±95.5	183.1±78.2	ns
2 years after HTX	163.2±135.5b	158.8±84.2a	ns
Lactate dehydrogenase (U/L)
Baseline	282.9±109.3	297.0±104.9	ns
2 years after HTX	196.9±86.8a	252.3±76.1a	0.0002
Alkaline phosphatase (U/L)
Baseline	149.3±96.9	145.1±114.4	ns
2 years after HTX	106.6±58.9b	95.9±54.8a	ns
Hemoglobin (g/dL)
Baseline	11.4±1.3	11.0±1.2	0.0080
2 years after HTX	12.7±1.6a	12.8±1.8a	ns
Thrombocytes (/nL)
Baseline	273.3±129.0	314.7±136.1	0.0189
2 years after HTX	244.3±66.5b	215.8±67.3a	0.0109
Leukocytes (/nL)
Baseline	10.0±5.2	10.1±4.5	ns
2 years after HTX	6.7±2.0a	6.3±2.0a	ns
Systolic blood pressure (mmHg)
Baseline	125.5±14.3	120.8±17.5	0.0317
2 years after HTX	126.2±15.8b	121.1±14.4b	0.0405
Diastolic blood pressure (mmHg)
Baseline	77.0±9.6	73.1±11.20	0.0060
2 years after HTX	77.2±9.6b	75.4±10.6b	ns

Notes:

^aP<0.05 vs baseline, statistically significant

^bP<0.05 vs baseline, ns.

Abbreviations: ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; CSA, cyclosporine A; GGT, gamma-glutamyl transferase; HDL, high-density lipoprotein; HTX, heart transplantation; LDL, low-density lipoprotein; MDRD, Modification of Diet in Renal Disease; ns, not statistically significant; SD, standard deviation; TAC, tacrolimus.