Table 1.
Summary of absorption pharmacokinetics of ropivacaine in Chinese patients
| Route of administration (number of patients) | Concentration of ropivacaine used | Total doses of ropivacaine | Cmax, arterial (μg/mL) | Cmax, venous (μg/mL) | tmax, arterial (min) | tmax, venous (min) | |
|---|---|---|---|---|---|---|---|
| Adult studies | |||||||
| Lee et al14 | Epidural block (24) | NA | 1.5 mg/kg | 1.31 (0.39) | 1.31 (0.5) | 8.8 (5.3–14.6) | 11.8 (6.6–21.1) |
| Karmakar et al16 | Thoracic paravertebral block (20) | 10 mg/mL | 2 mg/kg | 2.47 (0.5) | NA | 7.5 (2.5–25) | NA |
| Chen et al17 | Intra-articular administration (18) | 7.5 mg/mL | 150 mg | NA | 0.91 (0.4) | NA | 55.8 (33.6) |
| Child study | |||||||
| Karmakar et al18 | Caudal block (20) | 2 mg/mL | 2 mg/kg | NA | 0.67 (0.16) | NA | 61.9 (20.6) |
Note: Values are mean (SD), or mean (95% confidence interval) if SD could not be found in the paper.
Abbreviations: Cmax, maximum concentration; NA, related data not available; SD, standard deviation; tmax, time to Cmax.