Figure 1.

Effect of F₂ on the H₂O₂-induced increase in I_NCX.

Notes: (A) I–V curves of control (a), or in the presence of 100 μM H₂O₂ (b), H₂O₂ + F₂ (0.1, 1.0 or 10 μM) (c–e) and 5 mM NiCl₂ (f). Inset: ramp-pulse protocol. (B) I–V curves of net Ni²⁺-sensitive currents, obtained by subtracting the corresponding I–V curves in (A). (C) Concentration–response relationships of the inhibitory effect of F₂ on I_NCX. Outward currents were measured at +60 mV, inward currents were measured at −150 mV (n=9 cells/group). *P<0.05 outward currents versus inward currents.

Abbreviations: F₂, N-n-butyl haloperidol iodide; I_NCX, current of Na⁺/Ca²⁺ exchanger; I–V, current–voltage; H₂O₂, hydrogen peroxide; NiCl₂, nickel chloride; Ni²⁺, nickel ion.