Table 2 Single nucleotide polymorphisms (SNPs) as modifiers of lifetime risk in BRCA mutation carriers.
| BRCA1 mutation carriers | BRCA2 mutation carriers | |||||
|---|---|---|---|---|---|---|
| SNP | Gene/region | HR (95 % CI) | p value | HR (95 % CI) | p value | Reference |
| CI: confidence intervals; HR: hazard ratio; SNP: single nucleotide polymorphism. | ||||||
| rs1801320 | RAD51 | 1.59 (0.96–2.63) | 0.07 | 3.18 (1.39–7.27) | < 0.001 | 113 |
| rs1045485 | CASP8 | 0.85 (0.76–0.97) | 0.01 | 1.06 (0.88–1.27) | 0.60 | 114 |
| rs2981522 | FGFR2 | 1.02 (0.95–1.09) | 0.60 | 1.32 (0.20–1.45) | < 10−7 | 115 |
| rs3803662 | TOX3 | 1.11 (1.03–1.19) | < 0.01 | 1.15 (1.03–1.27) | < 0.01 | 115 |
| rs889312 | MAPK3K1 | 0.99 (0.93–1.06) | 0.90 | 1.12 (1.02–1.24) | 0.02 | 115 |
| rs3817198 | LSP1 | 1.05 (0.99–1.11) | 0.90 | 1.16 (1.07–1.25) | < 0.001 | 116 |
| rs13387042 | 2q35 | 1.14 (1.04–1.25) | < 0.01 | 1.18 (1.04–1.33) | < 0.01 | 116 |
| rs13281615 | 8q24 | 1.00 (0.94–1.05) | 0.90 | 1.06 (0.98–1.14) | 0.20 | 116 |
| rs8170 | MERIT40 | 1.26 (1.17–1.35) | < 10−8 | 0.90 (0.77–1.05) | 0.20 | 90 |
| rs2363956 | MERIT40 | 0.84 (0.80–0.89) | < 10−8 | 1.12 (0.99–1.27) | 0.07 | 90 |
| rs2046210 | 6q25.1 | 1.17 (1.11–1.23) | < 10−8 | 1.06 (0.99–1.14) | 0.09 | 117 |
| rs9397435 | 6q25.1 | 1.28 (1.18–1.40) | < 10−7 | 1.14 (1.01–1.28) | 0.03 | 117 |
| rs11249433 | 1p11.2 | 0.97 (0.92–1.02) | 0.2 | 1.09 (1.02–1.17) | 0.015 | 117 |