Predictor | Values | OR unadjusted1 | p value | OR adjusted2 | p value |
---|---|---|---|---|---|
1 OR estimated with simple logistic regression models; one model per predictor. 2 OR estimated by a multifactorial logistic regression model with variable selection, as described in the statistical methods section. ORs are adjusted for all other predictors. 3 The predictors age at menarche, number of live births, use of contraceptive pills ever, and body mass index were dropped during the variable selection process. | |||||
Age at menarche (years) | ≤ 11 | 1.00 (reference) | – | – 3 | |
12 | 0.50 (0.29, 0.89) | 0.02 | |||
13 | 0.63 (0.36, 1.12) | 0.12 | |||
14 | 0.37 (0.21, 0.68) | < 0.01 | |||
≥ 15 | 0.44 (0.23, 0.87) | 0.02 | |||
Menstrual cycle length (days) | ≤ 27 | 1.00 (reference) | – | 1.00 (reference) | – |
28 | 0.88 (0.58, 1.34) | 0.56 | 0.71 (0.43, 1.18) | 0.19 | |
≥ 29 | 1.73 (1.09, 2.75) | 0.02 | 2.33 (1.34, 4.04) | < 0.01 | |
Duration of menstrual bleeding (days) | ≤ 4 | 1.00 (reference) | – | 1.00 (reference) | – |
5 | 0.71 (0.47, 1.10) | 0.12 | 0.84 (0.48, 1.45) | 0.53 | |
≥ 6 | 1.48 (0.96, 2.29) | 0.08 | 1.86 (1.07, 3.24) | 0.03 | |
Number of pregnancies | 0 | 1.00 (reference) | – | 1.00 (reference) | – |
1 | 0.76 (0.49,1.18) | 0.21 | 0.71 (0.40, 1.28) | 0.25 | |
2 | 0.46 (0.29,0.72) | < 0.001 | 0.48 (0.27, 0.88) | 0.02 | |
≥ 3 | 0.30 (0.18,0.49) | < 0.00001 | 0.17 (0.08, 0.40) | < 0.0001 | |
Number of live births | 0 | 1.00 (reference) | – | – 3 | |
1 | 0.61 (0.40,0.93) | 0.02 | |||
2 | 0.45 (0.29,0.70) | < 0.001 | |||
≥ 3 | 0.30 (0.15,0.60) | < 0.001 | |||
Number of miscarriages | 0 | 1.00 (reference) | – | 1.00 (reference) | – |
≥ 1 | 0.87 (0.55,1.38) | 0.54 | 2.76 (1.28, 5.93) | < 0.01 | |
Use of contraceptive pill, ever | no | 1.00 (reference) | – | – 3 | |
yes | 0.48 (0.29,0.78) | < 0.01 | |||
Body mass index (kg/m2) | ≤ 20 | 1.00 (reference) | – | – 3 | |
20–25 | 1.01 (0.60, 1.70) | 0.98 | |||
25–30 | 1.02 (0.55, 1.92) | 0.94 | |||
> 30 | 0.90 (0.39, 2.11) | 0.81 | |||
Smoking | no | 1.00 (reference) | – | 1.00 (reference) | – |
yes | 2.09 (1.48,2.95) | < 0.0001 | 2.16 (1.39, 3.36) | < 0.001 |