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. 2014 Sep 4;6:74. doi: 10.12703/P6-74

Figure 2. Models of membrane tethers.

Figure 2.

Shown is an example of a long dimeric coiled-coil tether - the TGN golgin, golgin-245/p230, with the Arl1-binding site at the C-terminus (GRIP domain) indicated by the red oval shapes [14] and an example of a multiple subunit tethering complex - HOPS complex, which contains four shared subunits with the CORVET complex (in grey) and two unique subunits (orange), which bind to GTP-Rab7 [16]. The numbers refer to the identity of the Vps subunits.

Abbreviations: CORVET, class C core vacuole/endosome tethering; HOPS, homotypic fusion and vacuole protein sorting; TGN, trans-Golgi-network.