Table 3.
Frequency of Turner major clinical features and co-morbidities in relation to different karyotypes (Group A n=16, Group B n=36)
| Clinical feature | Group A | Group B | OR(95%CI) | P value |
|---|---|---|---|---|
|
| ||||
| n(%) | n(%) | |||
| Diagnosed at infancy | ||||
| Yes | 9(56.3) | 8(22.2) | 4.5(1.27–15.90) | 0.02 |
| No | 7(43.8) | 28(77.8) | 1 | |
| Short stature | ||||
| Yes | 16(100) | 28(77.8) | Incalculable | |
| No | 0 | 8(22.2) | ||
| CVS abnormalities | 0.051 | |||
| Yes | 8(50) | 8(22.2) | 3.50(0.99–12.29) | |
| No | 8(50) | 28(77.8) | 1 | |
| Renal abnormalities | 0.89 | |||
| Yes | 2(12.5) | 5(13.9) | 0.89(0.15–5.13) | |
| No | 14(87.5) | 31(86.1) | 1 | |
| Short neck | 0.054 | |||
| Yes | 9(56.3) | 10(27.8) | 3.34(0.98–11.4) | |
| No | 7(43.8) | 26(72.2) | 1 | |
| Lymphedema | 0.02 | |||
| Yes | 6(37.5) | 3(8.3) | 6.60(1.39–31.28) | |
| No | 10(62.5) | 33(91.7) | 1 | |
| Hypothyroidism | 0.49 | |||
| Yes | 3(18.8) | 10(27.8) | 0.60(0.14–2.56) | |
| No | 13(81.3) | 26(72.2) | 1 | |
| Eye abnormalities | 0.12 | |||
| Yes | 4(25.0) | 3(8.3) | 3.68(0.71–18.83) | |
| No | 12(75) | 33(91.7) | 1 | |
| Ears abnormalities | 0.71 | |||
| Yes | 8(50) | 16(44.4) | 1.25(0.38–4.07) | |
| No | 8(50) | 20(55.6) | ||
| Obesity | ||||
| Yes | 0 | 5(13.9) | Incalculable | |
| No | 16(100) | 31(86.1) | ||
| Amenorrhea* | ||||
| - Primary | 8(100) | 12(63.2) | Incalculable | |
| - Secondary | 0 | 7(36.8) | ||
Group A: Monosomy: 45,X; Group B: mosaic or other chromosome X abnormalities
OR: odds ratio, 95%CI: 95% confidence interval. P-value: Wald test.
*
Amenorrhea: based on 8 patients in Group A and 19 in Group B older than 12 years of age