Figure 7.

These photomicrographs acquired 24 hours post mNPH treatment, demonstrate the morphological changes observed in two different tumors which received an identical thermal dose (CEM 60). Both tumors show extensive uniform necrosis. The lower tumor demonstrates significant edema in the space between the tumor and underlying muscle (Zones 1 and 2). Although minor inflammation is seen, including mNP-containing macrophages, there was no hemorrhage or necrosis in the overlying skin or peritumoral tissue.