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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Pediatr Res. 2014 Apr 8;76(1):46–53. doi: 10.1038/pr.2014.53

Figure 2.

Figure 2

HIF-1α protein expression. Wildtype naïve have approximately twice the HIF-1α than HIF-1α knockout naïve (** p<0.002). (a) Mouse cortex after hypoxia only. In the wildtype mouse brain exposed to hypoxia, HIF-1 increased at 15 min (* p<0.02), at 4 h (* p<0.01) and at 24h (* p<0.05) compared to wildtype naïve. In addition, HIF-1α is elevated in the wildtype brain compared to HIF-1α knockout brain at 15 min (* p<0.02) and 4h (** p=0.001). HIF-1α does not change with hypoxia treatment in the HIF-1α knockout mice compared to HIF-1α knockout naïve at any time point. (b) Mouse cortex after HI. In the wildtype mouse brain exposed to HI, HIF-1α increased at 15 min compared to naïve (** p<0.002). In addition, HIF-1α is elevated in the wildtype brain compared to HIF-1α knockout brain at 15 min (* p<0.02). HIF-1α does not change after HI in the HIF-1α knockout cortex compared to naïve at any time point. (c) Mouse cortex after HPc and HI. HIF-1α does not change in the wildtype with HPc/HI. In the HIF-1α knockout, HIF-1α is decreased at 15 min compared to WT naïve (* p<0.05). White columns are wildtype. Black columns are HIF-1α knockout.