Figure 4.
ERK activation. Bar graph summarizes the ratio of pERK to ERK compared to wildtype naïve, there were no significant changes, (a) After hypoxia. There was a trend toward an increase in the wildtype cortex at 15 min (p=0.09). (b) After HI. There were trends toward an increase in HIFKO cortex at 15 min (p<0.14) and 4 h (p<0.09). There was a trend toward a decrease in wildtype at 15 min (p<0.06). (c) After HPc/HI. There was a trend toward a decrease in the wildtype cortex at 15 min, (p=0.06). White columns are wildtype. Black columns are HIF-1α knockout.