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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Curr Opin Allergy Clin Immunol. 2014 Oct;14(5):477–484. doi: 10.1097/ACI.0000000000000088

Table 2.

T cell subsets and their role in allergic responses.

T cell subset Cytokines Effector functions Involvement in Ocular Allergy SAC/PAC VKC AKC
Th2 IL-4
IL-5
IL-13		 IgE production
Eosinophil maturation and recruitment
Mucus production		 Immediate hypersensitivity, late phase reaction, and chronic disease + 58 ++ 64,65 ++ 64,65
Th1 IFN-γ Delayed-type hypersensitivity Chronic disease + 58,78 ++ 64,65 +++ 64,65
Th17 IL-17A/F Neutrophil recruitment Detected in severe disease −81 ?82* ?
Treg IL-10
TGF-β		 Suppression of effector T cells Frequencies are reduced Inline graphic100,101,102,105 ? ?
*

Source of IL-17 not determined.