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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: Cancer Res. 2014 Jul 18;74(18):5019–5031. doi: 10.1158/0008-5472.CAN-13-2845

Fig. 6. DMH1-treated NK cells are less phenotypically activated and have a reduced capacity to kill.

Fig. 6

In (A) NK cells were stimulated with IL-2, -12 and poly I:C for 12 hours in the absence or presence of the indicated doses of DMH1 or DMSO as vehicle control and the expression of CD69 and NKp46 was determined by flow cytometry. In (B and C) NK cells were treated as in (A) then co-cultured for 4-hours with K562 target cells before (B) LAMP1/CD107a expression was determined by flow cytometry and (C) cytotoxicity determined by specific lysis. One representative donor of three is shown in (A and B) while in (C) the specific lysis data are the mean ± 1SD of three separate donors. *p<0.01 vs. DMSO.