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. Author manuscript; available in PMC: 2015 Oct 28.
Published in final edited form as: Cancer Lett. 2014 Jul 25;353(2):248–257. doi: 10.1016/j.canlet.2014.07.030

Figure 4. Effect of the compromised immune system (nude mice) on systemic oxidative DNA damage and its inhibition by Tempol.

Figure 4

Three types of oxidative lesions, APE1, EndoIII, and hOGG1 (oxidized purines) were measured in normal tissues and tumors of 4 cohorts of mice, control (PBS-injected) and LLC-bearing mice without Tempol treatment and with Tempol treatment. Results are grouped by normal organs examined. Error bars, standard deviations in groups of mice (N=5). Gold asterisks, statistically significant difference between PBS and PBS+Tempol; black asterisks, statistically significant difference between tumors and PBS; blue asterisks, statistically significant difference between tumors and tumors+Tempol; red asterisks, statistically significant difference between tumors and PBS+Tempol. For the PBS+Tempol versus PBS, the reduction of APE1 lesions by Tempol exposure is only significant for stomach and spleen. *** (p<0.001).