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. 2014 Sep 2;14:649. doi: 10.1186/1471-2407-14-649

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© Rachner et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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DKK-1 tissue expression in prostate cancer. A) The prostate TMA was immunohistochemically stained for DKK-1. Exemplary samples of each staining intensity (0–3) are shown. B) Distribution of DKK-1 expression in benign prostate hyperplasia (BPH), tumour tissue (T) and adjacent non-tumor tissue (A) is shown by boxplots. *DKK-1 tissue expression differed significantly between the different pT stages and the BPH tissues (p < 0.0001). C) Kaplan Meier survival analyses for PCa patients on the TMA dichotomized according to the median DKK-1 scores into high and low DKK-1 expression revealed no significant differences in overall survival (log-rank test: p = 0.27).