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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Am J Med Genet A. 2014 Apr 3;164(10):2455–2460. doi: 10.1002/ajmg.a.36520

Figure 2.

Figure 2

Two pedigrees showing incomplete penetrance and variability of the phenotype depending on the number of WNT10A alleles affected. The fifth generation of the pedigree on the left is still too young for phenotype evaluation. An additional feature in this family is that the husband of the homozygous index patient (arrow) also carries the F228I variant, a 1 in 50 chance. The pedigree on the right also shows that two different tooth agenesis genes may contribute to the phenotypes, because the daughter has several missing teeth but no F228I mutation while her two homozygous brothers have severe tooth agenesis. F=Phenylalanine, I=Isoleucine