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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Am J Med Genet A. 2014 Apr 3;164(10):2455–2460. doi: 10.1002/ajmg.a.36520

Table I.

The WNT10A mutation Phe228Ile is unlikely to be a common polymorphism since its allele frequency is about 10 times higher in the tooth agenesis group than it is in several large control groups.

Source Ethnicity/ study
group		 Number of detected
alleles		 F228I allele
frequency
Our Tooth Agenesis (TA) study Caucasians with TA 127 Phe and 33 IIle 0.206
NCBI SNP data base Caucasians 3348 Phe and 67 Ile 0.02
NHLBI Exome Sequencing Project (ESP) Caucasians 8389 Phe and 209 Ile 0.024
NHLBI Exome Sequencing Project (ESP) African Americans 4370 Phe and 32 Ile 0.007
Bohring et al. 2009 Am J Hum Genet 85: 97 Caucasians without TA 396 Phe and 2 Ile 0.005