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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Brain Behav Immun. 2014 Jun 2;41:65–81. doi: 10.1016/j.bbi.2014.04.003

Figure 2.

Figure 2

Behavioral assessment of allodynia, hyperalgesia and depressive symptomps. A, Mice developed allodynia 1 week after CCI surgery and were completely recovered at week 12. B, Hyperalgesia was evident 2 weeks after surgery until week 7. Mean ± SEM of paw withdrawal threshold (g) and paw latency threshold (sec), respectively; **p<0.01, right paw vs left paw; ##p<0.01, week 8–11 vs 7 (allodynia) and week 5–7 vs 4 (hyperalgesia). C, Anhedonia paralleled the development and resolution of allodynia and hyperalgesia: CCI mice showed reduced sucrose preference 4 weeks after surgery until week 10 compared to sham animals, and were completely recovered at week 11. Mean ± SEM of sucrose preference; **p<0.01, CCI vs sham; ##p<0.01, week 6–10 vs week 5. D-E, Similarly, CCI mice showed a significant reduction of body weight gain (D) and degradation in the physical state of the coat (E), 5 and 4 weeks after injury, respectively, which were restored to the levels measured in sham mice 11 weeks later. **p<0.01, CCI vs sham; #p<0.05, ##p<0.01, weeks 6–10 vs week 5, and week 8–10 vs 7. (CCI, n = 34, sham, n = 26).

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