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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Drug Discov Today. 2014 May 29;19(9):1465–1470. doi: 10.1016/j.drudis.2014.05.013

Figure 1.

Figure 1

Hierachy of evidence for reversal of the target-specific oral anticoagulants (TSOACs). Studies of TSOAC reversal can be classified as one of four types. From lowest to highest quality of evidence, these include in vitro studies, animal studies, studies of TSOAC-treated healthy volunteers and studies of patients with TSOAC-associated bleeding. Systematic studies of patients with TSOAC-associated bleeding have not been completed. Major limitations of the other study types are shown in red.