Table 1.

Pharmacologic properties of target-specific oral anticoagulants

Target-specific oral anticoagulant	Target	Time to peak concentration (h)	Half-life (h)	Renal excretion
Dabigatran [28,29]	Thrombin	1–3	7–9a 7–17b	80–85%
Rivaroxaban[30–32]	Factor Xa	2–4	7–17a 12–13c 6–9b	36%
Apixaban [33–35]	Factor Xa	1–3	8–14a	25%
Edoxaban [36]	Factor Xa	1–2	6–11a 9–10b	36–45%
Betrixaban [36,37]	Factor Xa	3–4	19	<8%

^aHealthy adults, single dose.

^bHealthy adults, multiple doses.

^cHealthy elderly, single dose.