. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Am J Hematol. 2014 Jul 22;89(10):992–997. doi: 10.1002/ajh.23784

Table II. Multivariable meta-regression analysis for 5-year EFS.

CRT strategy	N studies^a	Adjusted^b 5-yr EFS of reference group (95% CI) and absolute rate differences of comparison subgroups (95% CI)	Omnibus p-value
CRT for all (reference)	33	64 (59, 68)	0.10
Risk-directed CRT	20	-6 (-14, 1)
CNS + only	7	-2(-13, 10)
No CRT	5	7 (-5, 19)

Some studies had missing data for asparaginase dose and were excluded from this analysis.

Adjusted for enrollment start year and asparaginase dose (continuous variable).

CI = confidence interval; CRT = cranial irradiation; EFS = event-free survival.