Figure 5. GPR81 is up-regulated in the tumor microenvironment.

(A) Tumor growth estimated using bioluminescent imaging of ASPC1-low or ASPC1-high cells stably transfected with luciferase, injected into the tail of the pancreas of athymic nude mice (n=8/group).

(B) Metastatic disease to the peritoneum estimated using bioluminescent imaging at 4 weeks at the time of sacrifice. Data are mean photons/sec/cm²/sr ± SEM.

(C) Representative images of immunohistochemistry of GPR81 expression in ASPC1-low or ASPC1-high tumor sections. Scale bar, 200μm. n ≥ 5/group.