Table 1.
In vitro expression of receptors of proangiogenic factors in the fetoplacental endothelium in normal third trimester human placenta.
| Angiogenic factors | Receptors of angiogenic factors | |||
|---|---|---|---|---|
| Gene symbol | Gene symbol | RefSeq ID | Mean intensity | Sd |
| VEGFA/PlGF | FLT1/VEGFR1 | NM_002019 | 9.5 | 0.59 |
|
| ||||
| VEGFB | KDR/VEGFR2 | NM_002253 | 10.5 | 1.43 |
|
| ||||
| FGF1/FGF2 | FGFR1 | NM_023110 | 9.5 | 0.25 |
| FGFR2 | NM_000141 | 5.3 | 0.11 | |
| FGFR3 | NM_000142 | 6.8 | 0.13 | |
| FGFR4 | NM_213647 | 6.1 | 0.09 | |
|
| ||||
| ANGPT1 | TIE1 | NM_005424 | 10.8 | 0.34 |
|
| ||||
| ANGPT2 | TEK/TIE2 | NM_000459 | 10.1 | 0.61 |
|
| ||||
| EPO | EPOR | NM_000121 | 7.6 | 0.15 |
|
| ||||
| TNFA | TNFR1 | NM_001065 | 10.8 | 0.15 |
| TNFR2 | NM_001066 | 8.6 | 0.57 | |
|
| ||||
| IL6 | IL6R | NM_000565 | 6.7 | 0.28 |
|
| ||||
| INS | INSR | NM_000208 | 6.4 | 0.70 |
|
| ||||
| IGF1 | IGF1R | NM_000875 | 7.5 | 0.54 |
|
| ||||
| IGF2 | IGF2R | NM_000876 | 9.3 | 0.48 |
|
| ||||
| LEP | LEPR | NM_002303 | 8.51 | 0.17 |
|
| ||||
| ADIPOQ | ADIPOR1 | NM_015999 | 11.6 | 0.11 |
| ADIPOR2 | NM_024551 | 9.6 | 0.18 | |
Mean mRNA signal intensities from arterial (n = 9) and venous (n = 9) endothelial cells measured by Affymetrix GeneChip Human 1.0 ST arrays (Cvitic et al., unpublished data). Signal intensities range from 1 to 13. Sd: standard deviation.