Table 3.
Univariate and multivariate analysis of predictive miRNA for PFS and OS in metastatic colorectal cancer patients (Training Cohort)
| VARIABLES | PFS | OS | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariate Analysis | Univariate Analysis | Mutivariate Analysis | |||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age | 0.99 [0.95-1.02] | 0.357 | 0.99 [0.95-1.04] | 0.765 | 1.01 [0.96-1.05] | 0.746 | 1.06 [1.01-1.12] | 0.027 |
| Sex | 0.51 [0.24-1.07] | 0.069 | 0.60 [0.26-1.40] | 0.232 | 0.42 [0.16-1.10] | 0.069 | 0.17 [0.05-0.54] | 0.003 |
| miR-107 | 2.12 [1.05-4.29] | 0.043 | 2.52 [1.18-5.42] | 0.017 | 2.65 [1.06-6.67] | 0.035 | 2.61 [0.86-7.92] | 0.091 |
| miR-337-5p | 2.27 [1.12-4.58] | 0.018 | 3.02 [1.34-6.83] | 0.008 | 2.53 [0.95-6.80] | 0.018 | 1.40 [0.42-4.69] | 0.584 |
| miR-99a-3p | 2.34 [1.11-4.93] | 0.030 | 2.50 [1.00-6.05] | 0.050 | 3.46 [1.26-9.53] | 0.008 | 1.99 [0.62-6.36] | 0.243 |
| miR-889 | 0.45 [0.22-0.94] | 0.073 | 0.40 [0.16-0.90] | 0.027 | 0.26 [0.10-0.71] | 0.017 | 0.15 [0.04-0.47] | 0.001 |
PFS: progression free survival; OS: overall survival; CI: confidence interval; HR: Hazard Ratio.
The bold value indicates a statistically significant result.