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Solid-phase binding assay. Dot blots of TM31C (A) and SCR (B) binding to Chol (#1) and different analogs: cholestanone (#2), ergosterol (#3), 5α-cholestane (#4), 7-dehydrocholesterol (#5), Chol-one (#6), and coprostanol (#7). (C and D) The results are presented in decreasing order of peptide (C) and SCR (D) binding to sterol analogs. The binding indicates the importance of the alcohol group in ring A for interaction with the scramblase TMD.
