Table 2. Characteristics and outcome of patients with severe sepsis.
| Variables | All patients (n = 484) | Survivors (n = 322) | Non-survivors (n = 162) | P Value |
| Age, median (IQR) | 66 (51–77) | 62 (47–74) | 71 (56–80) | <0.001 |
| Male sex | 336 (69.4%) | 216 (67.1%) | 120 (74.1%) | 0.115 |
| ICU admission categories | ||||
| Medical | 371 (76.7%) | 239 (74.2%) | 132 (81.5%) | 0.075 |
| Scheduled surgery | 39 (8.1%) | 27 (8.4%) | 12 (7.4%) | 0.709 |
| Emergency surgery | 74 (15.3%) | 56 (17.4%) | 18 (11.1%) | 0.070 |
| Reasons for ICU admission | ||||
| Respiratory disease | 259 (53.5%) | 163 (50.6%) | 96 (59.3%) | 0.072 |
| Gastrointestinal disease | 59 (12.2%) | 46 (14.3%) | 13 (8.0%) | 0.047 |
| Neurological disease | 49 (10.1%) | 35 (10.9%) | 14 (8.6%) | 0.443 |
| Cardiovascular disease | 46 (9.5%) | 27 (8.4%) | 19 (11.7%) | 0.237 |
| Trauma | 34 (7.0%) | 28 (8.7%) | 6 (3.7%) | 0.043 |
| Renal disease | 26 (5.4%) | 14 (4.3%) | 12 (7.4%) | 0.159 |
| Miscellaneous | 11 (2.3%) | 9 (2.8%) | 2 (3.7%) | 0.277 |
| Comorbidities | ||||
| No comorbidity | 158(32.6%) | 119(37.0%) | 39(24.1%) | 0.004 |
| Hypertension | 166(34.3%) | 102(31.7%) | 64(39.5%) | 0.087 |
| Diabetes mellitus | 85(17.6%) | 53(16.5%) | 32(19.8%) | 0.369 |
| Coronary artery disease | 83(17.1%) | 53(16.5%) | 30(18.5%) | 0.571 |
| COPD | 80(16.5%) | 48(14.9%) | 32(19.8%) | 0.176 |
| Cancer | 55(11.4%) | 27(8.4%) | 28(17.3%) | 0.004 |
| Hematologic malignancy | 10(2.1%) | 7(2.2%) | 3(1.9%) | 1.000 |
| Organ transplantation | 9(1.9%) | 4(1.2%) | 5(3.1%) | 0.169 |
| Chronic respiratory failure | 73(15.1%) | 44(13.7%) | 29(17.9%) | 0.219 |
| Chronic heart failure | 56(11.6%) | 23(7.1%) | 33(20.4%) | <0.001 |
| Immunocompromise | 48(9.9%) | 25(7.8%) | 23(14.2%) | 0.025 |
| Chronic renal failure | 13(2.7%) | 6(1.9%) | 7(4.3%) | 0.138 |
| Chronic liver dysfunction | 11(2.3%) | 7(2.2%) | 4(2.5%) | 1.000 |
| APACHE II, median (IQR) | 21(16–27) | 18(14–24) | 25(19–32) | <0.001 |
| SOFA on ICU day1, median (IQR) | 7.5(5–10) | 7(5–9) | 9(6.75–12) | <0.001 |
| Complications | ||||
| Septic shock | 119(24.6%) | 68(21.1%) | 51(31.5%) | 0.012 |
| Acute kidney injury | 201(41.5%) | 119(37.0%) | 82(50.6%) | 0.004 |
| ARDS | 265(54.8%) | 150(46.6%) | 115(71.0%) | <0.001 |
| ICU stay, days, median (IQR) | 7(4–15) | 7(4–14) | 9(4–17) | 0.067 |
APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, acute respiratory distress syndrome; COPD, Chronic obstructive pulmonary disease; ICU, Intensive care unit; IQR, interquartile range; SOFA, Sequential Organ Failure Assessment.