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. Author manuscript; available in PMC: 2015 Sep 28.
Published in final edited form as: J Control Release. 2014 Jun 28;190:314–330. doi: 10.1016/j.jconrel.2014.06.028

Figure 5.

Figure 5

Local aggregation of fluorophore-labeled temperature-sensitive ELP (ELP1) in hyperthermia-treated tumors increased accumulation (measured by fluorescence intensity of the extravascular compartment) over the course of heating, as compared to temperature-insensitive ELP (ELP2) with tumor hyperthermia or temperaturesensitive ELP without heat. Upon tumor cooling, resolubilization of local aggregates increased the accumulation of temperature-sensitive ELP in the extravascular space. Reprinted from [76]. Copyright 2007 American Association for Cancer Research.