Methods | Randomised, double blind, parallel group, no obvious enriched enrolment. Initial dose titration before fixed dose (13 weeks in total) | |
Participants | Pain persisting for at least 3 months after healing of herpes zoster skin rash, with average daily pain score of at least 40 mm/100 mm. Mean age 70 years, 54% male | |
Interventions | Pregabalin 150 mg daily, n = 86 Pregabalin 300 mg daily, n = 89 Pregabalin 600 mg daily, n = 97 Placebo daily, n = 97 |
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Outcomes | Proportion of patients with ≥ 30% or ≥ 50% decrease in mean pain score between endpoint and baseline, and other outcomes | |
Notes | Oxford quality score: R1, D1, W1 = 3/5 Pfizer sponsored |
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Risk of bias | ||
Item | Authors’ judgement | Description |
Adequate sequence generation? | Unclear | Stated to be randomised |
Allocation concealment? | Unclear | Not described |
Blinding? All outcomes |
Unclear | Stated to be double blind |