Methods	Randomised, double blind, parallel group. Single oral dose.
Participants	Oral surgery for removal of one or more third molars. Initial pain mild in 17%, and moderate or severe in others. Mean age 24 years, 59% female, 92% white
Interventions	Pregabalin 50 mg, n = 49 Pregabalin 300 mg, n = 50 Ibuprofen 400 mg, n = 49 Placebo, n = 50
Outcomes	Pain intensity difference, time to remedication
Notes	Oxford quality score: R1, D1, W1 = 3/5 Parke-Davis/Warner-Lambert sponsored
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Stated to be randomised
Allocation concealment?	Unclear	Not described
Blinding? All outcomes	Unclear	Stated to be blinded