Methods | Randomised, double blind, parallel group | |
Participants | Women undergoing laparoscopic hysterectomy. Mean age 50 years | |
Interventions | Diazepam 10 mg, n = 30 pregabalin 150 mg, n = 30 pregabalin 300 mg, n = 30 All given 1 hour preoperatively, and 12 hours later, when placebo was given to those initially given diazepam, and pregabalin 150 mg or 300 mg to those initially given pregabalin 150 mg or 300 mg (24 hr study) |
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Outcomes | Postoperative pain using 11-point numerical rating scale | |
Notes | Oxford quality score: R2, D2, W1 = 5/5 HUCH-EVO Committee and Paulo Foundation sponsored |
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Risk of bias | ||
Item | Authors’ judgement | Description |
Adequate sequence generation? | Yes | “computer generated random number table” |
Allocation concealment? | Yes | “opaque containers” |
Blinding? All outcomes |
Yes | “identical capsules” |