Methods	Randomised, double blind, parallel group, partial enriched enrolment. 5-day titration (5 weeks in total)
Participants	Painful diabetic neuropathy for 1-5 years, and pain at least 40/100 mm. Mean age 60 years, 40% female, 95% white
Interventions	Pregabalin 75 mg daily, n = 77 Pregabalin 300 mg daily, n = 81 Pregabalin 600 mg daily, n = 82, Placebo daily, n = 97
Outcomes	Proportion of patients with ≥ 50% decrease in mean pain score between endpoint and baseline, and other outcomes
Notes	Oxford quality score: R2, D2, W1 = 5/5 Pfizer sponsored
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	“random number table”
Allocation concealment?	Yes	Remote administration
Blinding? All outcomes	Yes	double dummy technique